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KMID : 0361020010440040418
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Korean Journal of Otolaryngology - Head and Neck Surgery
2001 Volume.44 No. 4 p.418 ~ p.422
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Expression of Laminin Activities in Rabbit Tracheal Mucosal Wound Healing Following CO2 Laser Incision
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이형석/Hyung Seok Lee
정연기/서인석/이승환/태경/Yean Gi Chung/In Seok Seo/Seung Hwan Lee/Kyung Tae
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Abstract
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Background and Objectives : Accuracy and predictability of damage to soft tissue and cartilage are important factors in choosing the most suitable laser for laryngotracheal operations. Hemostasis is also major significance when treating highly
vascular
lesions inside the tracheobronchial tree. The CO2 laser has a 10.6μm infrared wavelength and can be used to vaporize and excise tissue accurately with minimal thermal damage to surrounding tissues. Laminin is a family of extracellular matrix
glycoproteins localized in the basement membrane that separates epithelial cells from the underlying stroma. The biological activities of laminin to promote cell migration, growth and differentiation, suggest that laminin may have important roles
in
wound repair. Materials and Methods : The histologic changes and the expression of laminin activities following incision of tracheal mucosa by CO2 laser were studied over a period of 7 days in a rabbit model. Results : Some laminin positive
fragments
of the epithelial basement membranes could be seen in the wound at 12 hours. At 3 days, initial re-epithelialization was evident in the healing laser wound and an intensive positive staining for laminin was found in newly developed epithelial
tissue.
Re-epithelialization had proceeded to near completion by day 7 of surgery and the basement membranes containing laminin were much less conspicuous in the subepithelium at laser receiving sites than in the normal mucosa. Conclusion : Laminin plays
an
essential role in the initial cell proliferation of the basal cell layer by forming important landmarks for the migration of the epithelial cells.
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KEYWORD
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